What is Maropitant?

Maropitant is a neurokinin-1 (NK-1) receptor antagonist. NK-1 receptors are found in the brain and are responsible for mediating the nausea and vomiting response. By blocking these receptors, maropitant effectively prevents nausea and vomiting.

Maropitant Citrate API

Maropitant citrate is the most commonly used form of maropitant in veterinary medicine. It is a white to off-white crystalline powder that is soluble in water. Maropitant citrate is available in various dosage forms, including tablets, injectables, and oral solutions.

Maropitant Base API

Maropitant base is a free base form of maropitant. It is a yellow to orange powder that is less soluble in water than maropitant citrate. Maropitant base is not as commonly used as maropitant citrate, but it is sometimes used in combination with other medications.

Key Differences

The key differences between maropitant citrate and maropitant base are:

Chemical structure: Maropitant citrate is the salt form of maropitant, while maropitant base is the free base form.

Solubility: Maropitant citrate is more soluble in water than maropitant base.

Color: Maropitant citrate is a white to off-white powder, while maropitant base is a yellow to orange powder.

Dosage Forms: Maropitant citrate is available in more dosage forms than maropitant base.

Availability: Maropitant citrate is more readily available than maropitant base.

Which API is right for your pet?

The best API for your pet will depend on a number of factors, including the severity of their nausea and vomiting, their age and overall health, and any other medications they are taking. It is important to consult with your veterinarian to determine which API is the best choice for your pet.

Additional Considerations

Both maropitant citrate and maropitant base are generally safe and well-tolerated by dogs and cats. However, they may cause some side effects, such as drowsiness, diarrhea, and vomiting.

Maropitant citrate is considered to be more bioavailable than maropitant base, meaning that it is absorbed into the bloodstream more readily.

Maropitant base is less stable than maropitant citrate and may degrade more quickly.

Conclusion

Maropitant citrate and maropitant base are both effective medications for treating nausea and vomiting in dogs and cats. However, they differ in their chemical structure, properties, and availability. Consulting with your veterinarian will help you determine which API is the best choice for your pet.