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Sesil 3 yrs
Cannabidiol (CBD) is the main phytocannabinoid present in the Cannabis sativa plant. It lacks psychotomimetic and other psychotropic effects, which, on the contrary, the main plant compound Δ (9) -tetrahydrocannabinol (TGC), is able to counteract these effects. This property, together with the safety profile, provided the initial impetus for research on the pharmacological properties of CBD. It is now clear that CBD has therapeutic potential for a wide range of psychiatric disorders such as anxiety, depression, and psychosis.
Δ9-THC is a component of Cannabis sativa that increases food intake in animals and humans, an effect that is prevented by selective CB1 receptor antagonists. Cannabidiol (CBD) is another component of this plant that contributes to several opposite neuropharmacological effects compared to Δ9-THC. The mechanisms of action of CBD are still unclear, but under certain experimental conditions it can antagonize the effects of cannabinoid agonists, block anandamide reuptake, and act as a 5-HT1A receptor agonist. Both the cannabinoid and serotonergic systems are known to be involved in the control of food intake. CBD may influence changes in food intake induced by a CB1 or 5-HT1A receptor agonist, suggesting that its role as a possible regulator of food intake requires further study.