The story is set in 1270. only five years after D2R Items Tyrael took the rash decision to eliminate the poisoned Worldstone, Diablo D2R Ladder shows how the ruined fragments remain dormant and more than a handful of demons would not mind having the fragments.

The Lord of Terror's Soulstone destroyed in the Hellforgein Diablo's faithful followers are hoping to collect the fragments of the Worldstone to restore him to usher into a time of destruction and chaos.

In D2R Ladder it is assumed that Tyrael has died following the battle that ended at the end in Diablo 2. and Sanctuary is facing an uncertain fate as an arena for battle between both evil and good.

The mission of the game is to find and destroy the fragments of the broken Worldstone by the fan-favorite, recurring NPC Deckard Cain, before they are used to trigger an atomic catastrophe, the players are required to search for the earth while dealing with the consequences of Tyrael's actions.

The fragments of Worldstone are also attracting other old-fashioned evils, such as Skarn, who is the God of Damnation who wants to gather the pieces and make use of their power to control the human race.

Due to D2R Ladder's status as an epoch-making sequel to Diablo 2 and a prequel to Diablo 3. it occupies an intriguing position in the chronology. As an MMORPG It will most likely be updated regularly and will receive new content over a number of years, as well as expansions to the storyline that cheap D2R Ladder Items could eventually cover the entire period in between Diablo 2 in 1265 and Diablo 3 in 1285.